An update on sildenafil in the treatment of pulmonary arterial hypertension in the neonate
نویسنده
چکیده
Pulmonary arterial hypertension (PAH) refers to a group of diseases that are characterised by high pressure in the pulmonary artery and by pulmonary vascular resistance. Persistent PAH in the newborn is a condition whereby the pulmonary artery pressure does not decrease after birth, and may occur in as many as 6.8 in 1 000 live births. Phosphodiesterase type 5 (PDE-5) is the predominant PDE isoform in the lung which metabolises cyclic guanosine monophosphate (cGMP), and is upregulated in conditions associated with PAH. Thus, by selectively inhibiting PDE-5, the accumulation of intracellular cGMP is promoted by sildenafil citrate and nitric oxide-mediated vasodilatation is also enhanced. The article provides information on associated dosing regimens and reconstitution guidelines. © Medpharm S Afr Pharm J 2015;82(6):22-25
منابع مشابه
بررسی اثر تادالافیل خوراکی در کاهش پرفشاری شریان ریوی در کودکان و نوجوانان 5 ماهه تا 15 ساله
Introduction: Pulmonary arterial hypertension in children has consequences such as right ventricular failure and even death. Recently, the use of phosphodiesterase 5 inhibitors has been taken into account in the treatment of pulmonary hypertension, among which tadalafil is more acceptable by parents and patients due to its single dose per day compared to sildenafil which should be taken 4 times...
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Background and purpose: Pulmonary arterial hypertension (PAH) is a fatal disease affecting patients in all ages that could result in acute and chronic heart failure with high mortality rate. Oral sildenafil is approved to treat PAH in adults and recently in children. There are limited studies on the pharmacokinetics parameters of sildenafil, therefore, this study was designed to determine the p...
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